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Some patients turn to compounded versions for affordability

Commenters stated that such methodologies or reimbursement structures are often protected under intellectual property agreements or confidentiality clauses in hospital contracts, and requiring hospitals to encode such logic in the MRF could expose them to contractual breaches or legal liability

Comparison of Neurokinin A and Substance P on Cardiovascular and Airway Function in Man

A later 2020 paper on the AEDG peptide showed changes in expression of neurogenic differentiation markers in human gingival mesenchymal stem cells, which the authors interpreted within an epigenetic regulatory model